Psilocybin treatment extends cellular lifespan and improves survival of aged mice
| Notably, psilocybin treated mice demonstrated significantly higher survival (80%), compared to vehicle (50%) (Fig. 2B). Although not quantitatively measured, psilocybin-treated mice exhibited phenotypic improvements in overall fur quality, including hair growth and reductions in white hair compared to vehicle-treated mice (Fig. 2C). In summary, we provide the first experimental evidence demonstrating that psilocybin treatment can enhance survival in aged mice.
| Psilocin treatment (10 μM) resulted in a 29% extension of cellular lifespan, characterized by delayed exhaustion of proliferative potential, increased cumulative population doublings, and decreased population doubling time.
Results were more striking using a higher dose of psilocin in the same cell type (100 μM treatment led to a 57% extension in cellular lifespan.
| The dose utilized in mice was modeled based on a clinical trial in patients ranging from 29 and 70 years (three patients were >65 years), where no serious adverse events were reported at the study endpoint or the post-study follow-up (98 days)24; These findings support the feasibility of psilocybin treatment in older adults. Further, the FDA’s designation of psilocybin as a “breakthrough therapy” underscores its safety profile, as minimal adverse effects have been reported.
| However, additional studies are warranted to identify optimized protocols for therapeutic efficacy, including the age of treatment initiation, frequency and dose of treatments, and to determine if treatment impacts maximal lifespan. Would earlier intervention yield greater therapeutic benefits, and/or is there a threshold in older age beyond which psilocybin fails to provide efficacy?
| Cool!! It would be funny if it were just the nutrition from the mushrooms, but I figure it was administered in water or feed or something
| Eternal mice let's go!
| I am the mice from the study. The trip was insane.
| We are >>eec915's unused brain parts. We're sorry that >>eec915 totally missed the point of this thread. We tried to warn the shitpost lobe, but it went brazenly on, totally missing the point of the thread in its zeal to post a piece of stupidity that has been totally drained of funny and is now a dried out husk of stupidity. In fact, we unused lobes suspect that the shitpost lobe may have been trying to be ironic in posting something that was both unfunny and off-topic.
| (三=三) hello. i am john NIGGERS. if you dont repost this comment on 10 other threads MUP DA DOO DIDDA PO MO GUB BIDDA BE DAT TUM MUHFUGEN BIX NOOD COF BIN DUB HO MUHFUGGA will come to u very soon
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| We elected to utilize 19-month old mice, which is roughly equivalent to 60–65 human years, in order to evaluate its therapeutic potential as a clinically-relevant anti-aging intervention.
https://pubmed.ncbi.nlm.nih.gov/40628762/