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DissoDexter's Drug Safety Guides #2: PCP
| I know, its been a while since I did the first one, but I've had some minor run-ins with some clients of mine which took some of my time away. Everything should be solved now, so I have some time to try and help more of you party animals!
>The real disclaimer
Although the first paragraph was clearly a shill to the cop algorithms that may find me, I do seriously wish to try and protect people when it comes to these substances.
| I understand and agree completely that the best form of harm reduction is and always will be >complete and total abstinence and sobriety.
However, I also understand that humans will do as humans have been doing for hundreds or maybe thousands of years, and that as long as substances like this exist, they can and will be used and abused.
| The goal of this harm reduction guide is to educate the uneducated in proper usage of these substances in order to prevent needless deaths. Some of these can be used relatively safely, some cannot, but >all have the potential to hurt you and cause serious injury or death.
Note: I decided that I should be doing this much more professionally if I really want to help people, so the layout has been changed a little bit. If you like it or don't like it, let me know.
| >Summary:
Common Names: PCP, "Angel Dust", "Sherman" or "Sherm", "Wet", Sernyl
Substitutive Name: Phencyclidine
Systematic Name: 1-(1-phenylcyclohexyl)piperidine
Class: Hallucinogen
Psychoactive Class: Dissociative
Chemical Class: Arylcyclohexylamine
Routes of Administration: PCP can be smoked, taken orally, insufflated (snorted) or injected.
| Dosages:
>WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity.
PCP is dosed in milligrams (mg).
>Smoked Dosage
Threshold: 1-2 mg
Light: 2-4 mg
Common: 4-8 mg
Strong: 8-12mg
Heavy (Heavy doses may result in psychosis and mania.): 12+mg
>Smoked Duration
Total: 4-6 hours
Onset: 2-20 minutes
Come-up: 20-40 minutes
Peak: 2-3 hours
Offset: 1-2 hours
Aftereffects: 4-48 hours
| >Oral Dosage
Threshold: 1-3mg
Light: 3-5mg
Common: 5-10mg
Strong: 10-15mg
Heavy (Heavy doses may result in psychosis and mania.): 15+mg
>Oral Duration
Total: 4-8 hours
Onset: 30-90 minutes
Come-up: 40-120 minutes
Peak: 2-3 hours
Offset: 1-2 hours
Aftereffects: 4-48 hours
>Insufflated Dosage
Threshold: 1-2mg
Light: 2-4mg
Common: 4-8mg
Strong: 8-15mg
Heavy (Heavy doses may result in psychosis and mania.): 15+mg
| >Insufflated Duration
Total: 4-6 hours
Onset: 3-30 minutes
Come-up: 30-90 minutes
Peak: 2-3 hours
Offset: 1-2 hours
Aftereffects: 4-48 hours
Injected Dosage and Duration: Not available. Injecting PCP is excessively dangerous, and even a small dose can be potentially deadly.
| Interactions:
(Note: The interaction scale goes as follows
1=Low risk and positive synergy
2=Low risk and no synergy
3=Low risk and decreased effectiveness
4=Medium risk
5=High risk
6=Extra high risk (you will likely die!)
As PCP is such a potent substance, where very small amounts can lead to very potentially strong experiences, most interactions are generally not advised.)
| >Hallucinogens
Psychedelics: 4
Dissociatives: 4
Deliriants: 5
Atypicals: 4
Cannabinoids: 1
>Depressants
Benzodiazepines/Thienodiazepines: 5
Barbiturates: 5
Opioids: 3
GABAergics/Gabapentinoids: 5
Alcohol: 5
| >Stimulants
Amphetamines: 5
Phenidates: 5
Cathinones: 5
Caffeine: 4
Cocaine: 5
Entactogens: 5
Nootropics: 2
Others: 5
>Antidepressants:
Antidepressants: 6
Antipsychotics: 4
| Phencyclidine (also known as PCP, Angel Dust and others) is a synthetic dissociative substance of the arylcyclohexylamine chemical class that produces potent, long-lived dissociating, anesthetic, stimulating, disinhibiting and hallucinogenic effects when administered.
PCP acts primarily as an NMDA receptor antagonist, meaning it binds to and blocks the activity of the NMDA receptor, the receptor responsible for the transmission of neural impulses in the central nervous system.
| It was marketed in the 1950s as an anesthetic pharmaceutical drug but was taken off the market in 1965 due to the high prevalence of dissociating and hallucinogenic side effects it produced. Afterward, a similar structurally related compound named ketamine was discovered by researchers as a better-tolerated derivative for use as an anesthetic pharmaceutical drug.
PCP emerged as a recreational drug in mid-1967, under the name "The Peace Pill". It has stayed popular since.
| Since this time, a number of synthetic derivatives of PCP have been sold as dissociative drugs for both recreational and non-medical use. As an established "street drug", PCP is associated with compulsive abuse.
Due to its potent dissociative and stimulant effects, known habit-forming properties as well as an established toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.
| >Chemistry:
PCP, or phencyclidine, is a synthetic dissociative of the arylcyclohexylamine class. PCP contains cyclohexane, a six-member saturated ring, bonded to two additional rings at R1. One of these rings is a piperidine ring, a nitrogenous six member ring, bonded at its nitrogen group. The other ring is an aromatic phenyl ring. PCP is an initialism named from the first letters of the three constituent rings >phenyl, >cyclohexane and >piperidine.
| >Pharmacology:
PCP acts as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the notorious “k-hole.”
| PCP also acts as a dopamine-reuptake inhibitor and a serotonin reuptake inhibitorwith alleged µ-opioid affinity and typical dissociative effects. This provides an explanation for its euphoric and often stimulating properties.
| >Subjective effects
PCP is considerably more likely to induce psychosis and mania than other dissociatives and is therefore potentially dangerous even in a proper setting. The effects listed below should be taken with a grain of salt and will rarely (if ever) occur all at once, but heavier doses will increase the chances of inducing a full range of effects. Likewise, adverse effects become much more likely on higher doses and >may include serious injury or death.
| >Physical effects:
Pain relief
Dizziness
Motor control loss
Nausea
Optical sliding
Perception of bodily lightness
Physical autonomy
Spontaneous physical sensations
Physical euphoria
Tactile suppression
| >Visual suppressions:
Double vision
Frame rate suppression
Pattern recognition suppression
Visual acuity suppression
>Visual distortions:
Environmental cubism
Environmental orbism
Perspective distortions
Scenery slicing
Geometry, up to 8B level
| >Hallucinatory states:
At high doses, PCP can produce a full range of high-level hallucinatory states in a fashion that is less consistent and reproducible than that of many other commonly used hallucinogens. These effects include both:
Internal hallucination
External hallucination
| >Disconnective effects:
Cognitive disconnection
Physical disconnection
Visual disconnection - This eventually results in PCP's equivalent of the "k-hole" or more specifically, holes, spaces and voids alongside of structures.
>Cognitive effects:
The general head space of PCP is often described as particularly stimulating, euphoric and clear-headed in comparison to that of DXM, ketamine and other dissociative hallucinogens.
| The specific cognitive effects can be broken down into several separate subcomponents which are listed and described below:
Amnesia
Analysis suppression
Anxiety suppression
Cognitive euphoria
Compulsive redosing
Conceptual thinking
Creativity enhancement
Delusion
Depersonalization
Derealization
Disinhibition
Déjà vu
| Ego death
Ego inflation
Feelings of impending doom
Immersion enhancement
Introspection
Mania
Memory suppression
Psychosis - This effect is more common on PCP than other dissociatives.
Suicidal ideation
Thought acceleration & Thought deceleration
Thought connectivity
Thought disorganization
Time distortion
>Auditory effects:
Auditory distortion
Auditory hallucination
Auditory suppression
| >Toxicity and harm potential:
The long-term use of PCP may lead to schizophrenia-like psychotic episodes, severe lasting memory loss, disorganized thinking, depression, weight loss, liver abnormalities and rhabdomyolysis (skeletal muscle breakdown). It is strongly recommended that one use harm reduction practices, such as volumetric dosing, when using this substance to ensure the accurate administration of the intended dose.
| >Psychosis
PCP has been reported to cause psychosis and mania at a significantly higher rate than other dissociatives. Multiple scientific papers describe states of psychosis, mania, and/or delirium occurring after moderate to large doses of the drug were ingested.
| In one initial human trial, it was reported that one-sixth of the patients who had received anesthetic doses experienced acute psychosis. In some cases, it took up to a week or more to resolve. Similar results (although less severe) were reported during trials using subanesthetic doses of PCP for pain relief.
| It is very strongly recommended that one use extreme caution and harm reduction practices when using this drug. For example,
>Users should avoid taking the drug multiple days in a row or becoming addicted to it as this increases the risk of severe adverse effects.
>The recommended dosage range should not be exceeded as high doses can trigger adverse effects.
| >Users should start with extremely low doses and work their way up as slowly as possible. Volumetric liquid dosing should preferably be used due to the drug's potency; most standard milligram scales cannot accurately weigh out doses below 10-15mg.
>Compulsive redosing before one has fully sobered up is not recommended and can result in too high of a dose.
| Due to the risk of psychosis, it is not recommended to combine this drug with other substances, especially stimulants, psychedelics, or other dissociatives. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
| >Tolerance and addiction potential:
The chronic use of PCP can be considered highly addictive with a high potential for adverse side effects such as psychosis. In comparison to other dissociatives, PCP has been reported to be more addictive than MXE, diphenidine, ephenidine, and ketamine. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
| There have been multiple reports across the Matrix of people becoming seriously addicted daily users of this substance so serious precautions and considerations should be taken before trying this substance.
Tolerance to many of the effects of PCP develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects.
| After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). PCP presents cross-tolerance with all dissociatives, meaning that after the consumption of PCP, all dissociatives will have a reduced effect.
| Neurological effects:
Some studies found that, like other NMDA receptor antagonists, PCP can cause brain damage called Olney's lesions in rats. Studies conducted on rats showed that high doses of the NMDA receptor antagonist dizocilpine caused reversible vacuoles to form in certain regions of the rats' brains.
| >>>HOWEVER, all studies of Olney's lesions have only been performed on non-human animals and may not apply to humans. One unpublished study by Frank Sharp reportedly showed no damage by the NMDA antagonist ketamine (a similar drug) far beyond recreational doses but its validity is controversial since it was never published.
| PCP has also been shown to cause schizophrenia-like changes in N-acetylaspartate and N-acetylaspartylglutamate levels in the rat brain, which are detectable both in living rats and upon necropsy examination of brain tissue. It also induces symptoms in humans that mimic schizophrenia.
| >Urinary tract effects:
In terms of its long-term health effects when used repeatedly and excessively for extended periods of time, PCP seems to exhibit almost identical bladder and urinary tract problems to those produced by ketamine.
| Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
Urinary urgency - This can be described as a sudden, compelling need to urinate.
Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
Hematuria - Hematuria is visible blood in the urine.
| Incontinence - This is the uncontrolled leakage of urine.
>Legality
PCP is illegal in most of the known world for recreational usage besides Portugal. It can still be seen in some veterinary offices as an anaesthetic.
>My personal recommendations?
Okay, my name wouldn't be DissoDexter for no reason. Dissociative hallucinogens are my favorite drugs, and I'd be lying if I said I haven't had my fair share of good times using PCP.
| However, of all the dissociatives I've done (and trust me, I've done them >>>all), PCP is the one that I will never do again, as it is the one that brought me closest to my full-sanity breaking moment. I was in a sanitarium for a week after my last time using this drug, though when I did, I combined it with a concoction of other dissociatives. If my friends weren't there watching me, I would have probably killed myself to escape the hallucinatory hell. No joke.
| If you are going to do PCP, my advice? Always, always always ALWAYS have a tripsitter there to watch you and keep you from doing something fucking crazy, and never ever EVER go out in public! Stay indoors, in a safe and comfortable place.
Also: ALWAYS TEST YOUR DRUGS! Basic harm reduction begins with knowing what your substance actually is.
| Cut, mixed or spiked PCP can be potentially deadly in very small doses, and you don't want to have an experience you aren't prepared for anyway. Buy a test kit or send it to a lab. >You can even send it to me if you want and I'll test the shit for cheap for you. Send a tiny little baggy of your powder or liquid and I'll send it back with a chemical summary sheet of every substance inside of that powder for 5 nuyen.
| That's it for the second episode of Drug Safety Guides, and be on the lookout for my next trip report, where I explain the first time I ever smoked PCP-laced cannabis. Stay safe, you crazy animals.
>DissoDexter, /cyb/'s local psychonaut.
P.S.: If you have any questions, I'll answer them. ^^
| Uhm...
Uh...
So is this drug like, good or not?
| >>533086 From my personal experience, if used correctly it has the potential to be awesome euphoric bliss, but if used incorrectly it can be absolute hell. Follow the guide to use it correctly. :)
-DissoDexter
| Madlad. You have my respect. Stay safe friend.
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| >Disclaimer
Note to any and all badges that may read this: I do not condone the usage of illegal substances such as this one, and all users who plan to follow this guide do so at their own risk. User discretion is advised.
Okay, and with that bulldrek out of the way, hello and welcome to DissoDexter's >>>second episode of Drug Safety Guides!